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Electrophoresis. 2011 Jan;32(1):105-15. doi: 10.1002/elps.201000349. Epub 2010 Dec 3.

Preparation and application of organic-silica hybrid monolithic capillary columns.

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  • 1CAS Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R & A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, P. R. China.


Organic-silica hybrid monolithic columns have drawn more and more attention due to the ease of preparation and good mechanical stability in recent years. Many synthetic approaches have been developed and a variety of hybrid monolithic capillary columns have been prepared. The sol-gel process is well recognized in the fabrication of hybrid monolithic columns, which can be mainly classified as one-step, acid/base two-step procedures. The new approaches such as the "one-pot" and nano-scaled inorganic-organic hybrid reagent of polyhedral oligomeric silsesquioxane used as a cross-linker have also emerged for the preparation of hybrid monolithic columns. The applications of the organic-silica hybrid monolithic capillary columns for capillary electrochromatography, micro high-performance liquid chromatography, solid-phase micro-extraction and enzymatic reactor etc. are included in this review.

Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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