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Toxicol Int. 2010 Jul;17(2):59-63. doi: 10.4103/0971-6580.72671.

Reversal of Cadmium-induced Oxidative Stress in Chicken by Herbal Adaptogens Withania Somnifera and Ocimum Sanctum.

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  • 1Department of Pharmacology and Toxicology, NTR College of Veterinary Science, Gannavaram, Krishna (District), Hyderabad - 30, Andhra Pradesh, India.

Abstract

The present study was carried out to evaluate the herbal adaptogens Withania somnifera and Ocimum sanctum on cadmium-induced oxidative toxicity in broiler chicken. Cadmium administration at the rate of 100 ppm orally along with feed up to 28 days produced peroxidative damage, as indicated by increase in TBARS, reduction in glutathione (GSH) concentration in liver and kidney, and increase in catalase (CAT) and superoxide dismutase (SOD) of erythrocytes. Herbal adaptogens Withania somnifera roots and Ocimum sanctum leaf powder administration at the rate of 0.1% through feed reversed the antioxidant enzyme of RBC, i.e., CAT and SOD, nonenzymatic antioxidants GSH and lipid peroxidation marker TBARS of liver and kidney. Liver and kidney tissue repair and normal function was assessed by alanine aminotransaminase for liver and creatinine and blood urea nitrogen for kidney. In conclusion, oral administration of Withania somnifera root and Ocimum sanctum leaf powder prevented cadmium-induced peroxidation of tissues.

KEYWORDS:

Adaptogens; Ocimum sanctum; Withania somnifera; cadmium toxicity; chicken

PMID:
21170246
[PubMed]
PMCID:
PMC2997456
Free PMC Article
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