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Nat Neurosci. 2011 Jan;14(1):19-21. doi: 10.1038/nn.2719. Epub 2010 Dec 19.

Characterization of the proteome, diseases and evolution of the human postsynaptic density.

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  • 1Genes to Cognition Programme, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire, UK.

Abstract

We isolated the postsynaptic density from human neocortex (hPSD) and identified 1,461 proteins. hPSD mutations cause 133 neurological and psychiatric diseases and were enriched in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong protein sequence conservation in mammalian lineages, particularly in hub proteins, indicates conserved function and organization in primate and rodent models. The hPSD is an important structure for nervous system disease and behavior.

PMID:
21170055
[PubMed - indexed for MEDLINE]
PMCID:
PMC3040565
Free PMC Article
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