a. Distribution of hPSD nervous system diseases in 4 ICD–10 chapters (left chart) with Chapter VI expanded (right chart) to show further subclassifications.
b. Representative human and mouse phenotypes enriched in the hPSD.
Categories (bold) of human and mouse phenotypes with number of genes (hPSD genes). Heatmap compares enrichment of these phenotypes in 4 gene sets relative to the enrichment of the hPSD (shown in red). All other gene sets showed lower enrichment (darker colors with black representing no enrichment). Neuron. human cortical neuron transcriptome9; brain, whole mouse brain proteome; astrocyte, human astrocyte transcriptome10; and human genome.
Hs, human; Mm, mouse.
HPO and MPO phenotype IDs in brackets after each named phenotype.

a. Cumulative frequency plot of dN/dS values for hPSD and non–PSD genes expressed in cortical neurons9, and human genome. hPSD neuronal genes are more constrained than non–PSD neuronal genes (p < 10⁻¹¹).
b. Median mouse–human dN/dS shown for hPSD and subcellular structures expressed in cortical neurons9. Significance: p < 0.05 (*), p< 0.001 (***).
c, Boxplots of dN/dS distribution in hPSD hub proteins (>15 interactions, n = 23), non–hubs (≤15 interactions, n = 725) and the tandem affinity purification of PSD–95 complex14.