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Transplant Proc. 2010 Dec;42(10):3966-7. doi: 10.1016/j.transproceed.2010.09.136.

Renal transplantation following donation after cardiac death: impact of duration from withdrawal to asystole.

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  • 1Department of Organ Transplantation, St James’s University Hospital, Leeds, United Kingdom. Goldsmithpaul@hotmail.com

Abstract

Donation after cardiac death (DCD) allows for expansion of the donor pool, however, the process for DCD donation can lead to a donor's physiological instability before asystole. This may have a detrimental effect on graft and patient outcomes. We analyzed all 201 DCD donations at our unit from 2002 to 2009 and compared short versus long durations to asystole around the median time (20 min). Delayed graft function was comparable between the groups (P = .13), primary nonfunction was increased in the long duration to asystole group (P < .0001), and acute rejection was increased in the short duration group (P < .001). Five year patient survival was comparable (P = .6). In conclusion, long duration asystole may have an immediate effect on graft survival, but it has no overall detrimental effect on longer-term outcomes. Further studies are required to investigate the acceptable time to wait from withdrawal to asystole.

Copyright © 2010 Elsevier Inc. All rights reserved.

PMID:
21168601
[PubMed - indexed for MEDLINE]
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