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Mitochondrion. 2011 May;11(3):391-6. doi: 10.1016/j.mito.2010.12.002. Epub 2010 Dec 16.

A transcriptome screen in yeast identifies a novel assembly factor for the mitochondrial complex III.

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  • 1Centre de Génétique Moléculaire, CNRS FRE 3144, Avenue de la terrasse, Gif-sur-Yvette F-91190, France.

Abstract

Starting from a transcriptome based study of the spatio-temporal expression of yeast genes encoding mitochondrial proteins of unknown function, we have identified the gene BCA1 (YLR077W). A FISH analysis showed that the BCA1 mRNA co-localized with the mitochondrial network. Cellular fractionation revealed that Bca1 is bound to the mitochondrial inner-membrane and protrudes into the inter-membrane space. We show that Bca1 controls an early step in complex III assembly and that the supra-molecular organization of Bca1 is dependent upon the assembly level of complex III. Thus, Bca1 is a novel assembly factor for the respiratory complex III.

Copyright © 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

PMID:
21168530
[PubMed - indexed for MEDLINE]
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