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Dent Mater. 2011 Apr;27(4):329-38. doi: 10.1016/j.dental.2010.11.011. Epub 2010 Dec 16.

Effect of CPP-ACP addition on physical properties of zinc oxide non-eugenol temporary cements.

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  • 1Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Cooperative Research Centre for Oral Health Science, Melbourne Dental School, 720 Swanston Street, Victoria 3010, Australia. rhkwong@unimelb.edu.au



Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) is a milk derivative which holds nanoclusters of calcium and phosphate ions. The presence of CPP-ACP has been found to reduce demineralization and enhance remineralization in subsurface enamel and in dentin. Incorporation of CPP-ACP into luting cements has not been investigated. The aim of this study was to determine the effect on the physical properties of two commercially available zinc oxide non-eugenol temporary luting cements with incorporation of up to 8% (w/w) CPP-ACP.


Setting time, compressive strength, diametral tensile strength, film thickness and solubility tests were investigated for 0, 0.5, 1.0, 2.0, 3.0, 4.0 and 8.0% (w/w) CPP-ACP incorporated into Freegenol™ and Temp-Bond(®) NE. Tests were carried out based on ISO 3107 requirements.


Compressive and diametral tensile strengths progressively decreased with increasing concentrations of up to 8.0% (w/w) CPP-ACP incorporated into both Freegenol™ and Temp-Bond(®) NE. Setting time was delayed beyond ISO requirements. Film thickness was not adversely affected. Increased solubility of Temp-Bond(®) NE with 8.0% (w/w) CPP-ACP incorporation suggested an effect of the CPP-ACP on this property for this cement.


The incorporation of up to 8.0% (w/w) CPP-ACP into two zinc oxide non-eugenol luting cements has no adverse effects on the film thickness, compressive strength and diametral tensile strength of the cements investigated. Solubility investigations suggest that CPP-ACP leaches out of the zinc oxide non-eugenol luting cements into an aqueous environment.

Copyright © 2010 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

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