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Cytokine. 2011 Mar;53(3):271-81. doi: 10.1016/j.cyto.2010.11.013. Epub 2010 Dec 16.

Transcriptional repressors, corepressors and chromatin modifying enzymes in T cell development.

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  • 1Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.


Gene expression is regulated by the combined action of transcriptional activators and transcriptional repressors. Transcriptional repressors function by recruiting corepressor complexes containing histone-modifying enzymes to specific sites within DNA. Chromatin modifying complexes are subsequently recruited, either directly by transcriptional repressors, or indirectly via corepressor complexes and/or histone modifications, to remodel chromatin into either a transcription-friendly 'open' form or an inhibitory 'closed' form. Transcriptional repressors, corepressors and chromatin modifying complexes play critical roles throughout T cell development. Here, we highlight those genes that function to repress transcription and that have been shown to be required for T cell development.

Copyright © 2010 Elsevier Ltd. All rights reserved.

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