TRPC channel modulation in podocytes-inching toward novel treatments for glomerular disease

Pediatr Nephrol. 2011 Jul;26(7):1057-64. doi: 10.1007/s00467-010-1718-4. Epub 2010 Dec 16.

Abstract

Glomerular kidney disease is a major healthcare burden and considered to represent a sum of disorders that evade a refined and effective treatment. Excellent biological and genetic studies have defined pathways that go awry in podocytes, which are the regulatory cells of the glomerular filter. The question now is how to define targets for novel improved therapies. In this review, we summarize critical points around targeting the TRPC6 channel in podocytes.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Genetic Predisposition to Disease
  • Glomerular Filtration Rate / drug effects
  • Glomerulonephritis / diagnosis
  • Glomerulonephritis / drug therapy*
  • Glomerulonephritis / genetics
  • Glomerulonephritis / metabolism
  • Glomerulosclerosis, Focal Segmental / drug therapy
  • Glomerulosclerosis, Focal Segmental / metabolism
  • Humans
  • Kidney Glomerulus / drug effects*
  • Kidney Glomerulus / metabolism
  • Mutation
  • Phenotype
  • Podocytes / drug effects*
  • Podocytes / metabolism
  • Signal Transduction / drug effects
  • TRPC Cation Channels / drug effects*
  • TRPC Cation Channels / genetics
  • TRPC Cation Channels / metabolism
  • TRPC6 Cation Channel

Substances

  • TRPC Cation Channels
  • TRPC6 Cation Channel
  • TRPC6 protein, human