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World J Gastrointest Surg. 2010 Oct 27;2(10):306-13. doi: 10.4240/wjgs.v2.i10.306.

Intraductal papillary-mucinous neoplasia of the pancreas: Histopathology and molecular biology.

Author information

  • 1Caroline S Verbeke, Department of Histopathology, St James's University Hospital, Leeds LS9 7TF, United Kingdom.

Abstract

Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas is a clinically and morphologically distinctive precursor lesion of pancreatic cancer, characterized by gradual progression through a sequence of neoplastic changes. Based on the nature of the constituting neoplastic epithelium, degree of dysplasia and location within the pancreatic duct system, IPMNs are divided in several types which differ in their biological properties and clinical outcome. Molecular analysis and recent animal studies suggest that IPMNs develop in the context of a field-defect and reveal their possible relationship with other neoplastic precursor lesions of pancreatic cancer.

KEYWORDS:

Intraductal papillary mucinous neoplasm; Molecular pathology; Pancreas

PMID:
21160835
[PubMed]
PMCID:
PMC2999203
Free PMC Article
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