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World J Gastrointest Oncol. 2010 Mar 15;2(3):159-64. doi: 10.4251/wjgo.v2.i3.159.

Peroxisome proliferator-activated receptor γ and colorectal cancer.

Author information

  • 1Yun Dai, Wei-Hong Wang, Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China.

Abstract

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily and ligand-activated transcription factors. PPARγ plays an important role in adipocyte differentiation, lipid storage and energy dissipation in adipose tissue, and is involved in the control of inflammatory reactions as well as in glucose metabolism through the improvement of insulin sensitivity. Growing evidence has demonstrated that activation of PPARγ has an antineoplastic effect in tumors, including colorectal cancer. High expression of PPARγ is detected in human colon cancer cell lines and adenocarcinoma. This review describes the molecular mechanisms by which PPARγ regulates tumorigenesis in colorectal cancer, and examines current clinical trials evaluating PPARγ agonists as therapeutic agents for colorectal cancer.

KEYWORDS:

Colorectal cancer; Ligand; Peroxisome proliferator-activated receptors; Tumor suppression

PMID:
21160824
[PubMed]
PMCID:
PMC2999174
Free PMC Article
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