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    Kidney Int. 2011 Jan;79(1):10-3.

    20-HETE in acute kidney injury.

    Roman RJ, Akbulut T, Park F, Regner KR.

    Source

    Department of Pharmacology, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505, USA. rroman@umc.edu

    Abstract

    Ischemia/reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) that is associated with a patient mortality of up to 50%. Currently there are not effective pharmacologic therapies for AKI. This Commentary highlights recent evidence indicating that 20-HETE plays an important role in IRI and that drugs that target this pathway have potential as therapeutic agents for AKI.

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    PMID:
    21157458
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3146060
    Free PMC Article

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