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Br J Cancer. 2011 Feb 1;104(3):532-6. doi: 10.1038/sj.bjc.6606046. Epub 2010 Dec 14.

Analgesic use during pregnancy and risk of infant leukaemia: a Children's Oncology Group study.

Author information

  • 1Division of Pediatric Epidemiology and Clinical Research, University of Minnesota, 420 Delaware Street SE, MMC 422, Minneapolis, MN 55455, USA. ognja001@umn.edu

Abstract

BACKGROUND:

Infant leukaemia is likely initiated in utero.

METHODS:

We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression.

RESULTS:

With the exception of a reduced risk for infant acute myeloid leukaemias with non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use early in pregnancy (odds ratios=0.60; confidence intervals: 0.37-0.97), no statistically significant associations were observed for aspirin, non-aspirin NSAIDs, or acetaminophen use in early pregnancy or after knowledge of pregnancy.

CONCLUSION:

Overall, analgesic use during pregnancy was not significantly associated with the risk of infant leukaemia.

PMID:
21157452
[PubMed - indexed for MEDLINE]
PMCID:
PMC3049556
Free PMC Article
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