Science. 1990 Jul 20;249(4966):287-91.

Prevention of HIV-1 infection and preservation of CD4 function by the binding of CPFs to gp120.

Finberg RW, Diamond DC, Mitchell DB, Rosenstein Y, Soman G, Norman TC, Schreiber SL, Burakoff SJ.

Source

Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115.

Abstract

Infection by human immunodeficiency virus type-1 (HIV-1) is initiated when its envelope protein, gp120, binds to its receptor, the cell surface glycoprotein CD4. Small molecules, termed N-carbomethoxycarbonyl-prolyl-phenylalanyl benzyl esters (CPFs), blocked this binding. CPFs interacted with gp120 and did not interfere with the binding of CD4 to class II major histocompatibility complex molecules. One CPF isomer, CPF(DD), preserved CD4-dependent T cell function while inhibiting HIV-1 infection of H9 tumor cells and human T cells. Although the production of viral proteins in infected T cells is unaltered by CPF(DD), this compound prevents the spread of infection in an in vitro model system.

PMID:: 2115689; [PubMed - indexed for MEDLINE]

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Review The interaction of CD4 with HIV-1 gp120. [Semin Immunol. 1991]
Review The interaction of CD4 with HIV-1 gp120.
Silberman SL, Goldman SJ, Mitchell DB, Tong AT, Rosenstein Y, Diamond DC, Finberg RW, Schreiber SL, Burakoff SJ. Semin Immunol. 1991 May; 3(3):187-92.
CPF-DD is an inhibitor of infection by human immunodeficiency virus and other enveloped viruses in vitro. [Virology. 1992]
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Cited by 4 PubMed Central articles

Assays to detect and characterize human immunodeficiency virus type 1 (HIV-1) receptor antagonists, compounds that inhibit binding of the HIV-1 surface glycoprotein, gp120, to the CD4 receptor on human T lymphocytes. [Antimicrob Agents Chemother. 1...]
Assays to detect and characterize human immunodeficiency virus type 1 (HIV-1) receptor antagonists, compounds that inhibit binding of the HIV-1 surface glycoprotein, gp120, to the CD4 receptor on human T lymphocytes.
Clancy J, Tait-Kamradt A, Petitpas J, Manousos M, McGuirk PR, Subashi T, Watts P, Wondrack L. Antimicrob Agents Chemother. 1994 Sep; 38(9):2008-13.
Review Antiviral therapy for human immunodeficiency virus infections. [Clin Microbiol Rev. 1995]
Review Antiviral therapy for human immunodeficiency virus infections.
De Clercq E. Clin Microbiol Rev. 1995 Apr; 8(2):200-39.
Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules. [Proc Natl Acad Sci U S A. 1990]
Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules.
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