Cancer Genet Cytogenet. 2010 Dec;203(2):328-32.

Translocation (3;8)(q27;q24) in two cases of triple hit lymphoma.

Motlló C, Grau J, Juncà J, Ruiz N, Mate JL, Orna E, Navarro JT, Vives S, Sancho JM, Esteban D, Granada I, Feliu E, Ribera JM, Millá F.

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Hematology Service, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. krysmotllo@hotmail.com

Abstract

Unclassifiable lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma is a new category of B-cell lymphoma appearing in the new World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. This lymphoma usually shows MYC rearrangements with non-IGH genes in the setting of a complex karyotype possibly involving BCL2 and, less frequently, BCL6 rearrangements. According to the presence of two or three rearrangements, these lymphomas are called double-hit lymphomas or triple-hit lymphomas (THL), respectively. Here we report two cases of THL with MYC, BCL2, and BCL6 rearrangements and t(3;8)(q27;q24) diagnosed in one center in the last two years.

PMID:: 21156254; [PubMed - indexed for MEDLINE]

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Translocation (3;8)(q27;q24) in two cases of triple hit lymphoma.
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Cancer Genet Cytogenet. 2010 Dec ;203(2):328-32.

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Translocation (3;8)(q27;q24) in two cases of triple hit lymphoma.

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