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FEBS Lett. 2011 Jan 21;585(2):319-27. doi: 10.1016/j.febslet.2010.12.006. Epub 2010 Dec 13.

Regulation of Candida glabrata oxidative stress resistance is adapted to host environment.

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  • 1Max F. Perutz Laboratories, University of Vienna, Department of Biochemistry, Vienna, Austria.

Abstract

The human fungal pathogen Candida glabrata is related to Saccharomyces cerevisiae but has developed high resistance against reactive oxygen species. We find that induction of conserved genes encoding antioxidant functions is dependent on the transcription factors CgYap1 and CgSkn7 which cooperate for promoter recognition. Superoxide stress resistance of C. glabrata is provided by superoxide dismutase CgSod1, which is not dependent on CgYap1/Skn7. Only double mutants lacking both CgSod1 and CgYap1 were efficiently killed by primary mouse macrophages. Our results suggest that in C. glabrata the regulation of key genes providing stress protection is adopted to meet a host-pathogen situation.

Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

PMID:
21156173
[PubMed - indexed for MEDLINE]
PMCID:
PMC3022126
Free PMC Article
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