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Ann N Y Acad Sci. 2011 Jan;1217:60-76. doi: 10.1111/j.1749-6632.2010.05825.x. Epub 2010 Dec 13.

The IL-17 pathway as a major therapeutic target in autoimmune diseases.

Author information

  • 1C2N Diagnostics, St. Louis, Missouri, USA. helenhu@c2ndiagnostics.com

Abstract

Th17 cells are a subset of T helper cells that have been recently found to play important functions in host defense and the pathogenesis of various human autoimmune and inflammatory diseases. Th17 cells produce IL-17A, IL-17F, IL-22, and IL-21, of which IL-17A and IL-17F mediate many of the downstream pathologic functions of these cells. IL-17A and IL-17F signal through IL-17RA and IL-17RC heterodimeric receptors that are mainly expressed on tissue epithelial cells and fibroblasts. While IL-17A and IL-17F are important for host defense against many extracellular pathogens, they can also cause excessive tissue damage and exacerbate proinflammatory responses during autoimmunity. The IL-17 pathway, therefore, is a primary therapeutic target downstream of Th17 cells.

© 2010 New York Academy of Sciences.

PMID:
21155836
[PubMed - indexed for MEDLINE]
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