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Patholog Res Int. 2010 Mar 24;2010:613824. doi: 10.4061/2010/613824.

Endobronchial perineurioma: an unusual soft tissue lesion in an unreported location.

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  • 1Department of Pathology, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920, USA.

Abstract

We report the first case of an endobronchial perineurioma, a rare benign neoplasm typically occurring in soft tissue. A 53-year-old nonsmoking female presented with a three-month history of persistent bronchitis. A CT scan followed by bronchoscopy demonstrated an endobronchial lesion involving the left mainstem bronchus. Removal of the lesion by bronchoscopy was accomplished. The tumor was composed of bland spindle cells in a variably collagenized stroma. These cells had long cytoplasmic processes. No mitotic activity or necrosis was observed. Neoplastic cells were immunoreactive for epithelial membrane antigen (EMA), CD34, and claudin-1. Smooth muscle actin (SMA), desmin, and S-100 immunostains were all negative. Based on the morphologic appearance and immunophenotype, a diagnosis of perineurioma was rendered.

PMID:
21151724
[PubMed]
PMCID:
PMC2990242
Free PMC Article

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