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Biochim Biophys Acta. 2011 Oct;1812(10):1337-43. doi: 10.1016/j.bbadis.2010.11.014. Epub 2010 Dec 10.

Polycystic kidney disease: pathogenesis and potential therapies.

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  • 1Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent, inherited condition for which there is currently no effective specific clinical therapy. The disease is characterized by the progressive development of fluid-filled cysts derived from renal tubular epithelial cells which gradually compress the parenchyma and compromise renal function. Current interests in the field focus on understanding and exploiting signaling mechanisms underlying disease pathogenesis as well as delineating the role of the primary cilium in cystogenesis. This review highlights the pathogenetic pathways underlying renal cyst formation as well as novel therapeutic targets for the treatment of PKD. This article is part of a Special Issue entitled: Polycystic Kidney Disease.

Copyright © 2010 Elsevier B.V. All rights reserved.

PMID:
21146605
[PubMed - indexed for MEDLINE]
PMCID:
PMC3139769
Free PMC Article
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