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Trends Biochem Sci. 2011 Mar;36(3):159-69. doi: 10.1016/j.tibs.2010.10.002. Epub 2010 Dec 9.

How viruses hijack cell regulation.

Author information

  • 1Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany. davey@embl.de

Abstract

Viruses, as obligate intracellular parasites, are the pathogens that have the most intimate relationship with their host, and as such, their genomes have been shaped directly by interactions with the host proteome. Every step of the viral life cycle, from entry to budding, is orchestrated through interactions with cellular proteins. Accordingly, viruses will hijack and manipulate these proteins utilising any achievable mechanism. Yet, the extensive interactions of viral proteomes has yielded a conundrum: how do viruses commandeer so many diverse pathways and processes, given the obvious spatial constraints imposed by their compact genomes? One important approach is slowly being revealed, the extensive mimicry of host protein short linear motifs (SLiMs).

Copyright © 2010 Elsevier Ltd. All rights reserved.

PMID:
21146412
[PubMed - indexed for MEDLINE]
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