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Fertil Steril. 2011 Mar 15;95(4):1197-204. doi: 10.1016/j.fertnstert.2010.11.033. Epub 2010 Dec 13.

Pathogenesis, developmental consequences, and clinical correlations of human embryo fragmentation.

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  • 1Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94115-0916, USA.


This narrative review summarizes the current state of knowledge about human embryo fragmentation during IVF. The clinical relevance of fragmentation is discussed and evidence supporting a central role for the oocyte in the pathogenesis of fragmentation is presented. A mechanism of fragmentation as aberrant cell division involving the cytoskeleton is described along with the novel concept of membrane instability in relation to follicular high-density lipoprotein metabolism and cholesterol transport.

Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

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