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Fertil Steril. 2011 Apr;95(5):1805-8. doi: 10.1016/j.fertnstert.2010.11.028. Epub 2010 Dec 10.

Increased expression of tuberin in human uterine leiomyoma.

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  • 1Department of Biochemistry and Molecular Biology, Nankai University School of Medicine, Tianjin, People's Republic of China.


Female Eker rats harboring an insertional deletion in one copy of the tuberous sclerosis complex 2 (Tsc2) gene develop uterine leiomyoma, but the underlying mechanism of human uterine leiomyoma is not completely understood. To examine whether down-regulation of tuberin, a TSC2 gene product, is present in human uterine leiomyoma, we analyzed leiomyoma and matched myometrium tissues from 22 Chinese patients with Western blotting and real-time polymerase chain reaction analyses, and found that the expression of tuberin was significantly increased in leiomyoma tissues compared with matched myometrium tissues with inhibition of both the mammalian target of rapacmycin pathway and mitogen-activated protein kinase pathways.

Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

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