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Fertil Steril. 2011 Apr;95(5):1788.e11-3. doi: 10.1016/j.fertnstert.2010.11.020. Epub 2010 Dec 8.

In vitro fertilization surrogacy in rare coexisting Mayer-Rokitansky-Kuster-Hauser syndrome and triple X karyotype.

Author information

  • 1The IVF Unit, Assaf Harofeh Medical Center, Zerifin, Israel. araziel@asaf.health.gov.il

Abstract

OBJECTIVE:

To report the responses to IVF surrogacy attempts in a female with a heretofore never described combination of Mayer-Rokitansky-Kuster-Hauser (MRHK) syndrome and triple X karyotype.

DESIGN:

Case report.

SETTING:

Reproductive unit of a university-affiliated medical center.

PATIENT(S):

A 29-year-old female diagnosed as having both MRHK syndrome and a triple X (47XXX) karyotype.

INTERVENTION(S):

Five cycles of IVF surrogacy.

MAIN OUTCOME MEASURE(S):

Recovery of oocytes after controlled ovarian stimulation.

RESULT(S):

A maximum of five oocytes were retrieved by percutaneous abdominal aspiration of a single subcostal left ovary. After five unsuccessful IVF trials due to low ovarian response attributed to her coexisting MRHK syndrome and triple X karyotype, the patient's choice was oocyte donation.

CONCLUSION(S):

An abnormal karyotype can coexist with MRKH syndrome, albeit very rarely, and probably accounts for a low ovarian response to attempts to achieve IVF surrogacy.

Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

PMID:
21144508
[PubMed - indexed for MEDLINE]
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