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Sheng Wu Gong Cheng Xue Bao. 2010 Sep;26(9):1176-86.

[Reconstruction and application of genome-scale metabolic network model].

[Article in Chinese]

Author information

  • 1State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. mingll@jiangnan.edu.cn

Abstract

The exploitation of microbial manufacture process (MMP) in industrial biotechnology requires a comprehensive understanding and an efficient modification of microorganism physiology. The availability of genome sequences and accumulation of -omics data allow us to understand of microbial physiology at the systems level, and genome-scale metabolic model (GSMM) represents a valuable framework for integrative analysis of metabolism of microorganisms. Genome scale metabolic models are reconstructed based on a combination of genome sequence and the more detailed biochemical knowledge, and these reconstructed models can be used for analyzing and simulating the operation of metabolism in response to different perturbations. Here we describe the reconstruction protocols for GSMM in further detail and provide the perspective of GSMM.

PMID:
21141107
[PubMed - indexed for MEDLINE]
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