Psychopharmacology (Berl). 1990;101(3):414-20.

Schizophrenic-like sensorimotor gating abnormalities in rats following dopamine infusion into the nucleus accumbens.

Swerdlow NR, Braff DL, Masten VL, Geyer MA.

Source

Department of Psychiatry, University of California, San Diego, La Jolla 92093.

Abstract

Previous studies have demonstrated that several dopamine agonists disrupt sensorimotor gating as measured by prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats. Schizophrenic patients also exhibit deficits in PPI when the prepulse precedes the startle stimulus by less than 500 ms. In experiment 1, dopamine (0-40 micrograms) infused directly into the nucleus accumbens in rats caused a dose-dependent decrease in PPI at prepulse intervals shorter than 500 ms. In experiment 2, this effect of accumbens dopamine infusion on sensorimotor gating was found to vary with changes in prepulse intensity. These findings strongly suggest that increased mesolimbic dopamine activity is one substrate of the sensorimotor gating deficits in rats that are caused by treatment with dopamine agonists; similar substrates might mediate deficits in PPI exhibited by schizophrenic patients.

PMID:: 2114026; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

GABAergic projection from nucleus accumbens to ventral pallidum mediates dopamine-induced sensorimotor gating deficits of acoustic startle in rats. [Brain Res. 1990]
GABAergic projection from nucleus accumbens to ventral pallidum mediates dopamine-induced sensorimotor gating deficits of acoustic startle in rats.
Swerdlow NR, Braff DL, Geyer MA. Brain Res. 1990 Nov 5; 532(1-2):146-50.
Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine. [Psychopharmacology (Berl). 1990]
Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine.
Swerdlow NR, Mansbach RS, Geyer MA, Pulvirenti L, Koob GF, Braff DL. Psychopharmacology (Berl). 1990; 100(3):413-6.
Carbachol infusion into the dentate gyrus disrupts sensorimotor gating of startle in the rat. [Psychopharmacology (Berl). 1991]
Carbachol infusion into the dentate gyrus disrupts sensorimotor gating of startle in the rat.
Caine SB, Geyer MA, Swerdlow NR. Psychopharmacology (Berl). 1991; 105(3):347-54.
Review Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients. [Arch Gen Psychiatry. 1994]
Review Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients.
Swerdlow NR, Braff DL, Taaid N, Geyer MA. Arch Gen Psychiatry. 1994 Feb; 51(2):139-54.
Review Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia. [Schizophr Bull. 1998]
Review Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia.
Swerdlow NR, Geyer MA. Schizophr Bull. 1998; 24(2):285-301.

See reviews... See all...

Cited by 7 PubMed Central articles

The melanin-concentrating hormone (MCH) system modulates behaviors associated with psychiatric disorders. [PLoS One. 2011]
The melanin-concentrating hormone (MCH) system modulates behaviors associated with psychiatric disorders.
Chung S, Verheij MM, Hesseling P, van Vugt RW, Buell M, Belluzzi JD, Geyer MA, Martens GJ, Civelli O. PLoS One. 2011; 6(7):e19286. Epub 2011 Jul 19.
Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: effects of antipsychotics. [Front Behav Neurosci. 2010]
Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: effects of antipsychotics.
Xu H, Yang HJ, McConomy B, Browning R, Li XM. Front Behav Neurosci. 2010 Mar 18; 4:8. Epub 2010 Mar 18.
The effects of kappa-opioid receptor ligands on prepulse inhibition and CRF-induced prepulse inhibition deficits in the rat. [Psychopharmacology (Berl). 2010]
The effects of kappa-opioid receptor ligands on prepulse inhibition and CRF-induced prepulse inhibition deficits in the rat.
Tejeda HA, Chefer VI, Zapata A, Shippenberg TS. Psychopharmacology (Berl). 2010 Jun; 210(2):231-40. Epub 2010 Mar 16.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Schizophrenic-like sensorimotor gating abnormalities in rats following dopamine ...
Schizophrenic-like sensorimotor gating abnormalities in rats following dopamine infusion into the nucleus accumbens.
Psychopharmacology (Berl). 1990 ;101(3):414-20.

PubMed
Lack of effect of sublingual salvinorin A, a naturally occurring kappa opioid, i...
Lack of effect of sublingual salvinorin A, a naturally occurring kappa opioid, in humans: a placebo-controlled trial.
Psychopharmacology (Berl). 2011 Apr ;214(4):933-9. Epub 2010 Dec 8 .

PubMed
TRPV1-lineage neurons are required for thermal sensation.
TRPV1-lineage neurons are required for thermal sensation.
EMBO J. 2011 Feb 2 ;30(3):582-93. Epub 2010 Dec 7 .

PubMed
Dermatologic aspects and cutaneous manifestations of sarcoidosis.
Dermatologic aspects and cutaneous manifestations of sarcoidosis.
G Ital Dermatol Venereol. 2010 Dec ;145(6):733-45.

PubMed
Serum levels of pregnancy-associated endometrial alpha 2-globulin (alpha 2-PEG),...
Serum levels of pregnancy-associated endometrial alpha 2-globulin (alpha 2-PEG), a glycosylated beta-lactoglobulin homologue, in successful and unsuccessful assisted conception.
Hum Reprod. 1990 May ;5(4):421-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Schizophrenic-like sensorimotor gating abnormalities in rats following dopamine infusion into the nucleus accumbens.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 7 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information