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Cell Res. 2011 Jan;21(1):6-21. doi: 10.1038/cr.2010.170. Epub 2010 Dec 7.

Expanding role of ubiquitination in NF-κB signaling.

Author information

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

Abstract

Best known for its role in targeting protein degradation by the proteasome, ubiquitin modification has also emerged as an important mechanism that regulates cell signaling through proteasome-independent mechanisms. The role of ubiquitin as a versatile signaling tag is characteristically illustrated in the NF-κB pathways, which regulate a variety of physiological and pathological processes in response to diverse stimuli. Here, we review the role of ubiquitination in different steps of the NF-κB signaling cascades, focusing on recent advances in understanding the mechanisms of protein kinase activation by polyubiquitin chains in different pathways that converge on NF-κB.

PMID:
21135871
[PubMed - indexed for MEDLINE]
PMCID:
PMC3193409
Free PMC Article

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