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J Nerv Ment Dis. 2010 Dec;198(12):864-9. doi: 10.1097/NMD.0b013e3181fe7258.

The development of subjective quality of life over the first 2 years in first-episode psychosis.

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  • 1Department of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.


The main aim of this study was to examine changes in subjective quality of life (general s-QoL) in patients with first-episode psychosis from baseline to 2 years follow-up. A total of 201 of 252 patients had full quality of life assessment at both baseline and at 2 years. Repeated measure analyses of variance were done to evaluate the development over time, and multiple linear regression analyses to evaluate predictors of change. These patients with a first-episode psychosis showed a significant improvement in general s-QoL during the first 2 years of treatment. Improvements in general s-QoL were associated with increase in excitative symptoms and with improvements in depressive symptoms, global functioning, level of daily activities, level of social activities, and perceived general health.

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