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Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22122-7. doi: 10.1073/pnas.1016401107. Epub 2010 Dec 6.

JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis.

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  • 1Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Pathology, Division of Rheumatology,School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease marked by bone and cartilage destruction. Current biologic therapies are beneficial in only a portion of patients; hence small molecules targeting key pathogenic signaling cascades represent alternative therapeutic strategies. Here we show that c-Jun N-terminal kinase (JNK) 1, but not JNK2, is critical for joint swelling and destruction in a serum transfer model of arthritis. The proinflammatory function of JNK1 requires bone marrow-derived cells, particularly mast cells. Without JNK1, mast cells fail to degranulate efficiently and release less IL-1β after stimulation via Fcγ receptors (FcγRs). Pharmacologic JNK inhibition effectively prevents arthritis onset and abrogates joint swelling in established disease. Hence, JNK1 controls mast cell degranulation and FcγR-triggered IL-1β production, in addition to regulating cytokine and matrix metalloproteinase biosynthesis, and is an attractive therapeutic target in inflammatory arthritis.

PMID:
21135226
[PubMed - indexed for MEDLINE]
PMCID:
PMC3009768
Free PMC Article
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