Display Settings:

Format

Send to:

Choose Destination
Microbes Infect. 2011 Apr;13(4):322-30. doi: 10.1016/j.micinf.2010.11.004. Epub 2010 Dec 4.

Early eradication of persistent Salmonella infection primes antibody-mediated protective immunity to recurrent infection.

Author information

  • 1Department of Pediatrics, University of Minnesota School of Medicine, Center for Infectious Disease and Microbiology Translational Research, USA.

Abstract

Typhoid fever is a systemic, persistent infection caused by host-specific strains of Salmonella. Although the use of antibiotics has reduced the complications associated with primary infection, recurrent infection remains an important cause of ongoing human morbidity and mortality. Herein, we investigated the impacts of antibiotic eradication of primary infection on protection against secondary recurrent infection. Using a murine model of persistent Salmonella infection, we demonstrate protection against recurrent infection is sustained despite early eradication of primary infection. In this model, protection is not mediated by CD4(+) or CD8(+) T cells because depletion of these cells either alone or in combination prior to rechallenge does not abrogate protection. Instead, infection followed by antibiotic-mediated clearance primes robust levels of Salmonella-specific antibody that can adoptively transfer protection to naïve mice. Thus, eradication of persistent Salmonella infection primes antibody-mediated protective immunity to recurrent infection.

Copyright © 2010 Institut Pasteur. Published by Elsevier SAS. All rights reserved.

PMID:
21134485
[PubMed - indexed for MEDLINE]
PMCID:
PMC3056909
Free PMC Article

Images from this publication.See all images (6)Free text

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk