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Acta Psychiatr Scand. 1990 May;81(5):432-6.

The antidepressant potential of oral S-adenosyl-l-methionine.

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  • 1Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114.

Abstract

S-adenosyl-l-methionine (SAMe), a naturally occurring brain metabolite, has previously been found to be effective and tolerated well in parenteral form as a treatment of major depression. To explore the antidepressant potential of oral SAMe, we conducted an open trial in 20 outpatients with major depression, including those with (n = 9) and without (n = 11) prior history of antidepressant nonresponse. The group as a whole significantly improved with oral SAMe: 7 of 11 non-treatment-resistant and 2 of 9 treatment-resistant patients experienced full antidepressant response. Side effects were mild and transient.

PMID:
2113347
[PubMed - indexed for MEDLINE]
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