Acta Psychiatr Scand. 1990 May;81(5):432-6.

The antidepressant potential of oral S-adenosyl-l-methionine.

Rosenbaum JF, Fava M, Falk WE, Pollack MH, Cohen LS, Cohen BM, Zubenko GS.

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Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114.

Abstract

S-adenosyl-l-methionine (SAMe), a naturally occurring brain metabolite, has previously been found to be effective and tolerated well in parenteral form as a treatment of major depression. To explore the antidepressant potential of oral SAMe, we conducted an open trial in 20 outpatients with major depression, including those with (n = 9) and without (n = 11) prior history of antidepressant nonresponse. The group as a whole significantly improved with oral SAMe: 7 of 11 non-treatment-resistant and 2 of 9 treatment-resistant patients experienced full antidepressant response. Side effects were mild and transient.

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Shu L, Lee NP. West J Med. 2000 Oct; 173(4):229-30.

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The antidepressant potential of oral S-adenosyl-l-methionine.
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Acta Psychiatr Scand. 1990 May ;81(5):432-6.

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