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Nat Rev Neurol. 2010 Dec;6(12):653-4. doi: 10.1038/nrneurol.2010.176.

Neuro-oncology: Genetic variation in pediatric and adult brain tumors.

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  • 1Department of Medical Oncology, Bellaria Hospital, Via Altura 3, Bologna, Italy. alba.brandes@yahoo.it


Two new studies suggest that pediatric medulloblastomas and high-grade gliomas are genetically different from the same tumors in adults. Age-dependent gene expression might affect tumor biology; therefore, therapies for adult medulloblastomas or gliomas might not produce the same clinical outcomes in pediatric patients, and vice versa.

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