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Nat Rev Neurol. 2010 Dec;6(12):651-3. doi: 10.1038/nrneurol.2010.165.

Epilepsy: Risk of suicidal behavior with antiepileptic drugs.

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  • 1Department of Neuroscience, Mental Health and Sensory Functions, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1035, Rome, Italy.


Antiepileptic drugs (AeDs) are receiving increasing attention for a possible association with suicidal thoughts and behaviors. Several recent studies examining this association, however, have yielded inconsistent findings, particularly in terms of the risk of suicidal behavior conferred by specific AeDs. In patients with epilepsy, heightened suicide risk is also attributable to comorbid psychiatric conditions.

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