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J Antimicrob Chemother. 2011 Feb;66(2):235-9. doi: 10.1093/jac/dkq448. Epub 2010 Dec 5.

Emerging antiretroviral drug interactions.

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  • 1Division of Infectious Diseases, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA.


With HIV-infected patients living longer and recommendations to initiate antiretrovirals (ARVs) being made earlier, the likelihood for potential drug-drug interactions between ARVs and concurrent medications used to manage co-morbid conditions will increase. In order to maximize the clinical benefit and minimize potential toxicity of ARVs and co-administered medications, it is important for clinicians to recognize significant drug-drug interactions. This article highlights clinically significant drug-drug interactions with antituberculosis agents, antimalarials, anticoagulants, chemotherapeutic agents and pulmonary antihypertensive agents when they are co-administered with newer ARVs (e.g. darunavir, raltegravir, maraviroc and etravirine).

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