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Eukaryot Cell. 2011 Feb;10(2):272-5. doi: 10.1128/EC.00133-10. Epub 2010 Dec 3.

Interaction between the Candida albicans high-osmolarity glycerol (HOG) pathway and the response to human beta-defensins 2 and 3.

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  • 1Department of Microbiology, Columbia University, New York, New York 10032, USA.


Human β-defensins 2 and 3 are small cationic peptides with antimicrobial activity against the fungal pathogen Candida albicans. We found that hog1 and pbs2 mutants were hypersensitive to treatment with these peptides, pointing to a role of the high-osmolarity glycerol (HOG) pathway in the response to defensin-induced cell injury.

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