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    Neurosci Lett. 2011 Feb 1;489(1):43-7. Epub 2010 Dec 2.

    Essential role of toll-like receptor 2 in morphine-induced microglia activation in mice.

    Zhang Y, Li H, Li Y, Sun X, Zhu M, Hanley G, Lesage G, Yin D.

    Source

    Department of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States.

    Abstract

    Opioids are powerful pain relievers, but also potent inducers of dependence and tolerance. Chronic morphine administration (via subcutaneous pellet) induces morphine dependence in the nucleus accumbens, an important dependence region in the brain, yet the cellular mechanisms are mostly unknown. Toll-like receptor 2 (TLR2) plays an essential function in controlling innate and inflammatory responses. Using a knockout mouse lacking TLR2, we assessed the contribution of TLR2 to microglia activation and development of morphine dependence. We report here that mice deficient in TLR2 inhibit morphine-induced the levels of microglia activation and proinflammatory cytokines. Moreover, in TLR2 knockout mice the main symptoms of morphine withdrawal were significantly attenuated. Our data reveal that TLR2 plays a critical role in morphine-induced microglia activation and dependence.

    Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

    PMID:
    21130144
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3018547
    Free PMC Article

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