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Rev Med Suisse. 2010 Oct 20;6(267):1970, 1972-5.

[Should we believe in the interaction between proton pump inhibitors (PPI) and clopidogrel].

[Article in French]

Author information

  • 1Service de médecine interne générale, Département de médecine interne, HUG, 1211 Genève 14. Valentina.Pelloni@hcuge.ch

Abstract

Recently, some authors have examined the possibility of an interaction between proton pump inhibitors (especially omeprazole) and clopidogrel. Pharmacodynamically, this interaction is proven and leads to a reduction in anti-aggregation activity. Nevertheless, the clinical implications are not fully clarified. We are all waiting for a randomised prospective study assessing specifically this issue. Meanwhile, caution is recommended when prescribing PPI in patients taking clopidogrel.

PMID:
21125730
[PubMed - indexed for MEDLINE]
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