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Rev Med Suisse. 2010 Oct 20;6(267):1970, 1972-5.

[Should we believe in the interaction between proton pump inhibitors (PPI) and clopidogrel].

[Article in French]

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  • 1Service de médecine interne générale, Département de médecine interne, HUG, 1211 Genève 14.


Recently, some authors have examined the possibility of an interaction between proton pump inhibitors (especially omeprazole) and clopidogrel. Pharmacodynamically, this interaction is proven and leads to a reduction in anti-aggregation activity. Nevertheless, the clinical implications are not fully clarified. We are all waiting for a randomised prospective study assessing specifically this issue. Meanwhile, caution is recommended when prescribing PPI in patients taking clopidogrel.

[PubMed - indexed for MEDLINE]
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