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Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1):a005108. doi: 10.1101/cshperspect.a005108.

Extracellular matrix: functions in the nervous system.

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  • 1The Scripps Research Institute, Department of Cell Biology, Dorris Neuroscience Center, La Jolla, California 92037, USA.

Abstract

An astonishing number of extracellular matrix glycoproteins are expressed in dynamic patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia express receptors that mediate interactions with specific extracellular matrix molecules. Functional studies in vitro and genetic studies in mice have provided evidence that the extracellular matrix affects virtually all aspects of nervous system development and function. Here we will summarize recent findings that have shed light on the specific functions of defined extracellular matrix molecules on such diverse processes as neural stem cell differentiation, neuronal migration, the formation of axonal tracts, and the maturation and function of synapses in the peripheral and central nervous system.

PMID:
21123393
[PubMed - indexed for MEDLINE]
PMCID:
PMC3003458
Free PMC Article

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