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J Crohns Colitis. 2010 Nov;4(5):591-3. doi: 10.1016/j.crohns.2010.04.001. Epub 2010 Jun 16.

Suicide attempt in ulcerative colitis patient after 4 months of infliximab therapy--a case report.

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  • 1Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.


In the summary of product characteristics of infliximab (IFX), psychiatric side effects are reported to be rare, and in literature only limited data exist. This report presents a case of a patient with ulcerative colitis who developed a depression with psychotic symptoms during IFX therapy and made a suicide attempt 4 months after the initiation of therapy. Although the time between start of IFX therapy and onset of symptoms could suggest a correlation, this, of course, does not prove that IFX was the causative factor for his depression and suicide attempt.

Copyright © 2010. Published by Elsevier B.V.

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