Abstract
Elevated plasma LDL cholesterol concentrations result primarily from two mechanisms: LDL overproduction and loss of hepatic receptor-dependent LDL removal. This knowledge can be used to lower plasma cholesterol and thereby retard or even reverse atherosclerosis. Pharmacologic agents are useful, as are dietary approaches.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Arteriosclerosis / blood
-
Arteriosclerosis / etiology
-
Arteriosclerosis / therapy
-
Cholesterol, Dietary / adverse effects
-
Cholesterol, Dietary / metabolism
-
Cholesterol, LDL / blood
-
Cholesterol, LDL / physiology*
-
Humans
-
Liver / physiology
-
Receptors, LDL / physiology
Substances
-
Cholesterol, Dietary
-
Cholesterol, LDL
-
Receptors, LDL