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Nat Rev Neurosci. 2011 Jan;12(1):9-15. doi: 10.1038/nrn2949. Epub 2010 Dec 1.

How does PKMζ maintain long-term memory?

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  • 1The Robert F. Furchgott Center of Neural and Behavioural Science, Department of Physiology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, USA. tsacktor@downstate.edu


Most of the molecular mechanisms contributing to long-term memory have been found to consolidate information within a brief time window after learning, but not to maintain information during memory storage. However, with the discovery that synaptic long-term potentiation is maintained by the persistently active protein kinase, protein kinase Mζ (PKMζ), a possible mechanism of memory storage has been identified. Recent research shows how PKMζ might perpetuate information both at synapses and during long-term memory.

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