Am J Trop Med Hyg. 2010 Dec;83(6):1308-10. doi: 10.4269/ajtmh.2010.10-0180.

Using giant African pouched rats to detect tuberculosis in human sputum samples: 2009 findings.

Poling A, Weetjens BJ, Cox C, Mgode G, Jubitana M, Kazwala R, Mfinanga GS, Huis In 't Veld D.

Source

Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling, Morogoro, Tanzania. alan.poling@wmich.edu

Abstract

In 2009, giant African pouched rats trained to detect tuberculosis (TB) evaluated sputum samples from 10,523 patients whose sputum had previously been evaluated by smear microscopy. Microscopists found 13.3% of the patients to be TB-positive. Simulated second-line screening by the rats revealed 620 new TB-positive patients, increasing the case detection rate by 44%. These data suggest that the rats may be useful for TB detection in developing countries, although further research is needed.

PMID:: 21118940; [PubMed - indexed for MEDLINE]
PMCID:: PMC2990050

Free PMC Article

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

PubReader: A whole new way to read scientific literature at PubMed Central.

Related citations in PubMed

Using giant African pouched rats to detect tuberculosis in human sputum samples: 2010 findings. [Pan Afr Med J. 2011]
Using giant African pouched rats to detect tuberculosis in human sputum samples: 2010 findings.
Mahoney AM, Weetjens BJ, Cox C, Beyene N, Mgode G, Jubitana M, Kuipers D, Kazwala R, Mfinanga GS, Durgin A, et al. Pan Afr Med J. 2011; 9:28. Epub 2011 Jul 18.
African pouched rats for the detection of pulmonary tuberculosis in sputum samples. [Int J Tuberc Lung Dis. 2009]
African pouched rats for the detection of pulmonary tuberculosis in sputum samples.
Weetjens BJ, Mgode GF, Machang'u RS, Kazwala R, Mfinanga G, Lwilla F, Cox C, Jubitana M, Kanyagha H, Mtandu R, et al. Int J Tuberc Lung Dis. 2009 Jun; 13(6):737-43.
Diagnosis of tuberculosis by trained African giant pouched rats and confounding impact of pathogens and microflora of the respiratory tract. [J Clin Microbiol. 2012]
Diagnosis of tuberculosis by trained African giant pouched rats and confounding impact of pathogens and microflora of the respiratory tract.
Mgode GF, Weetjens BJ, Nawrath T, Cox C, Jubitana M, Machang'u RS, Cohen-Bacrie S, Bedotto M, Drancourt M, Schulz S, et al. J Clin Microbiol. 2012 Feb; 50(2):274-80. Epub 2011 Nov 30.
Review Commercial serological antibody detection tests for the diagnosis of pulmonary tuberculosis: a systematic review. [PLoS Med. 2007]
Review Commercial serological antibody detection tests for the diagnosis of pulmonary tuberculosis: a systematic review.
Steingart KR, Henry M, Laal S, Hopewell PC, Ramsay A, Menzies D, Cunningham J, Weldingh K, Pai M. PLoS Med. 2007 Jun; 4(6):e202.
Review A review of the diagnosis and treatment of smear-negative pulmonary tuberculosis. [Int J Tuberc Lung Dis. 2000]
Review A review of the diagnosis and treatment of smear-negative pulmonary tuberculosis.
Colebunders R, Bastian I. Int J Tuberc Lung Dis. 2000 Feb; 4(2):97-107.

See reviews... See all...

Cited by 6 PubMed Central articles

Pouched rats' detection of tuberculosis in human sputum: comparison to culturing and polymerase chain reaction. [Tuberc Res Treat. 2012]
Pouched rats' detection of tuberculosis in human sputum: comparison to culturing and polymerase chain reaction.
Mahoney A, Weetjens BJ, Cox C, Beyene N, Reither K, Makingi G, Jubitana M, Kazwala R, Mfinanga GS, Kahwa A, et al. Tuberc Res Treat. 2012; 2012:716989. Epub 2012 Jul 9.
Tuberculosis detection by giant african pouched rats. [Behav Anal. 2011]
Tuberculosis detection by giant african pouched rats.
Poling A, Weetjens B, Cox C, Beyene N, Durgin A, Mahoney A. Behav Anal. 2011 Spring; 34(1):47-54.
Using giant African pouched rats to detect tuberculosis in human sputum samples: 2010 findings. [Pan Afr Med J. 2011]
Using giant African pouched rats to detect tuberculosis in human sputum samples: 2010 findings.
Mahoney AM, Weetjens BJ, Cox C, Beyene N, Mgode G, Jubitana M, Kuipers D, Kazwala R, Mfinanga GS, Durgin A, et al. Pan Afr Med J. 2011; 9:28. Epub 2011 Jul 18.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Using giant African pouched rats to detect tuberculosis in human sputum samples:...
Using giant African pouched rats to detect tuberculosis in human sputum samples: 2009 findings.
Am J Trop Med Hyg. 2010 Dec ;83(6):1308-10. doi: 10.4269/ajtmh.2010.10-0180.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: