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J Mol Cell Cardiol. 2011 Oct;51(4):518-28. doi: 10.1016/j.yjmcc.2010.11.014. Epub 2010 Nov 28.

Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failure.

Author information

  • 1Cardiology Division, VA Medical Center, San Francisco, CA, USA. brian_jensen@med.unc.edu

Abstract

Evidence from cell, animal, and human studies demonstrates that α1-adrenergic receptors mediate adaptive and protective effects in the heart. These effects may be particularly important in chronic heart failure, when catecholamine levels are elevated and β-adrenergic receptors are down-regulated and dysfunctional. This review summarizes these data and proposes that selectively activating α1-adrenergic receptors in the heart might represent a novel and effective way to treat heart failure. This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure."

Published by Elsevier Ltd.

PMID:
21118696
[PubMed - indexed for MEDLINE]
PMCID:
PMC3085055
Free PMC Article

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