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Genome Biol. 2010;11(11):R117. doi: 10.1186/gb-2010-11-11-r117. Epub 2010 Nov 30.

Comparative genomics reveals birth and death of fragile regions in mammalian evolution.

Author information

  • 1Department of Computer Science & Engineering, University of South Carolina, 301 Main St, Columbia, SC 29208, USA. maxal@cse.sc.edu

Abstract

BACKGROUND:

An important question in genome evolution is whether there exist fragile regions (rearrangement hotspots) where chromosomal rearrangements are happening over and over again. Although nearly all recent studies supported the existence of fragile regions in mammalian genomes, the most comprehensive phylogenomic study of mammals raised some doubts about their existence.

RESULTS:

Here we demonstrate that fragile regions are subject to a birth and death process, implying that fragility has a limited evolutionary lifespan.

CONCLUSIONS:

This finding implies that fragile regions migrate to different locations in different mammals, explaining why there exist only a few chromosomal breakpoints shared between different lineages. The birth and death of fragile regions as a phenomenon reinforces the hypothesis that rearrangements are promoted by matching segmental duplications and suggests putative locations of the currently active fragile regions in the human genome.

© 2010 Alekseyev et al.; licensee BioMed Central Ltd.

PMID:
21118492
[PubMed - indexed for MEDLINE]
PMCID:
PMC3156956
Free PMC Article

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