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IUBMB Life. 2010 Nov;62(11):803-11. doi: 10.1002/iub.391.

Detection of bulky DNA lesions: DDB2 at the interface of chromatin and DNA repair in eukaryotes.

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  • 1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA.


Bulky DNA damage is corrected by the nucleotide excision repair (NER) pathway. Although the core biochemical mechanism of NER is understood, details including lesion recognition and repair in the context of chromatin remain to be elucidated. As more data become available, the complexity of lesion recognition in chromatin is becoming clear. This review will discuss current knowledge of DNA damage recognition in the context of chromatin, with a focus on the roles of chromatin remodeling and the specific lesion recognition protein DDB2 (DNA damage-binding protein 2) in chromatin repair. Additionally, we propose a model that ubiquitination-mediated DDB2 dissociation from chromatin, not its degradation, is important for GG-NER progression.

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