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Cell Mol Life Sci. 2011 Feb;68(3):353-68. doi: 10.1007/s00018-010-0579-0. Epub 2010 Nov 30.

The role of HLA-G in immunity and hematopoiesis.

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  • 1CEA, I2BM, Service de Recherches en Hemato-Immunologie, 75475 Paris, France. Edgardo.Carosella@cea.fr

Abstract

The non-classical HLA class I molecule HLA-G was initially shown to play a major role in feto-maternal tolerance. Since this discovery, it has been established that HLA-G is a tolerogenic molecule which participates to the control of the immune response. In this review, we summarize the recent advances on (1) the multiple structures of HLA-G, which are closely associated with their role in the inhibition of NK cell cytotoxicity, (2) the factors that regulate the expression of HLA-G and its receptors, (3) the mechanism of action of HLA-G at the immunological synapse and through trogocytosis, and (4) the generation of suppressive cells through HLA-G. Moreover, we also review recent findings on the non-immunological functions of HLA-G in erythropoiesis and angiogenesis.

PMID:
21116680
[PubMed - indexed for MEDLINE]
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