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Metallomics. 2011 Mar;3(3):262-6. doi: 10.1039/c0mt00052c. Epub 2010 Nov 29.

Insights into the thermodynamics of copper association with amyloid-β, α-synuclein and prion proteins.

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  • 1Department of Chemistry, Duke University, Durham, NC 27708, USA. Lian.hong@duke.edu

Abstract

This review examines recent studies on the thermodynamics of copper association with amyloid-β, α-synuclein and prion protein, with an eye towards using this information to understand the etiology of associated neurodegenerative diseases. A variety of binding affinities and binding sites, which are essential to understand the function and consequence of copper-protein interaction, have been reported for copper to these three neurobiologic systems. This current review reconciles the disparate models presented in the literature.

PMID:
21116546
[PubMed - indexed for MEDLINE]
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