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Behav Brain Res. 2011 Apr 15;218(2):335-40. doi: 10.1016/j.bbr.2010.11.042. Epub 2010 Nov 27.

Dorso- and ventro-lateral prefrontal volume and spatial working memory in schizotypal personality disorder.

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  • 1Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.

Abstract

Schizotypal personality disorder (SPD) individuals and borderline personality disorder (BPD) individuals have been reported to show neuropsychological impairments and abnormalities in brain structure. However, relationships between neuropsychological function and brain structure in these groups are not well understood. This study compared visual-spatial working memory (SWM) and its associations with dorsolateral prefrontal cortex (DLPFC) and ventrolateral prefrontal cortex (VLPFC) gray matter volume in 18 unmedicated SPD patients with no BPD traits, 18 unmedicated BPD patients with no SPD traits, and 16 healthy controls (HC). Results showed impaired SWM in SPD but not BPD, compared with HC. Moreover, among the HC group, but not SPD patients, better SWM performance was associated with larger VLPFC (BA44/45) gray matter volume (Fisher's Z p-values <0.05). Findings suggest spatial working memory impairments may be a core neuropsychological deficit specific to SPD patients and highlight the role of VLPFC subcomponents in normal and dysfunctional memory performance.

Published by Elsevier B.V.

PMID:
21115066
[PubMed - indexed for MEDLINE]
PMCID:
PMC3049905
Free PMC Article

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