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Retrovirology. 2010 Nov 29;7:99. doi: 10.1186/1742-4690-7-99.

Current concepts regarding the HTLV-1 receptor complex.

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  • 1CNRS UMR8147, Universite Rene Descartes, Paris 5, 161 Rue de Sèvres, 75743 Paris Cedex 15, France.


The identity of the Human T lymphotropic Virus type 1 (HTLV-1) receptor remained an unsolved puzzle for two decades, until the recent demonstration that three molecules, Glucose Transporter 1, Neuropilin-1 and Heparan Sulfate Proteoglycans are involved in HTLV-1 binding and entry. Despite these advances, several questions remain unanswered, including the precise role of each of these molecules during virus entry. In light of the most recent data, we propose a model of the HTLV-1 receptor complex and discuss its potential impact on HTLV-1 infection.

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