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Asia Pac J Clin Oncol. 2010 Dec;6(4):306-19. doi: 10.1111/j.1743-7563.2010.01322.x. Epub 2010 Oct 19.

Clinical relevance of FLT3 receptor protein expression in Indian patients with acute leukemia.

Author information

  • 1Immunohistochemistry and Flowcytometry Division, The Gujarat Cancer and Research Institute, New Civil Hospital Compound, Asarwa, Ahmedabad, India. ihcgcri@hotmail.com

Abstract

AIM:

FLT3 is a receptor tyrosine kinase that plays an important role in the pathogenesis of leukemia. The present study aimed to evaluate the role of FLT3 protein in patients with acute leukemia.

METHOD:

FLT3 protein was quantified by flow cytometry on leukemic blasts using CD135 antibody in 160 patients with acute leukemia.

RESULTS:

We demonstrated FLT3 protein expression (>20%) in 82% of acute myeloid leukemia (AML), 60% of B-lineage acute lymphoblastic leukemia (B-ALL), 23% of T-lineage acute lymphoblastic leukemia (T-ALL) and 80% of biphenotypic leukemia. Further, FLT3 expression was seen to be significantly higher in AMLM2, M4, and M5 than in AMLM3. In B-ALL, FLT3 was found to be higher in pro-B-ALL and lower in early B-ALL. A CD34 expression >20% was associated with FLT3 positive B-ALL. When correlated with disease status, all patients in the relapsed AML group had FLT3 > 20% at diagnosis. Unlike AML, the relapsed group of B-ALL showed a lower incidence of FLT3 than the remission group.

CONCLUSION:

In summary, our data imply that there is frequent overexpression of the FLT3 protein in AML and B-ALL patients of Indian origin. In future, the FLT3 protein level may be used to select patients for whom FLT3 inhibitor therapy may be indicated.

© 2010 Blackwell Publishing Asia Pty Ltd.

PMID:
21114781
[PubMed - indexed for MEDLINE]
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