Format

Send to:

Choose Destination
See comment in PubMed Commons below
Radiat Prot Dosimetry. 2011 Feb;143(2-4):358-64. doi: 10.1093/rpd/ncq389. Epub 2010 Nov 27.

A new view of radiation-induced cancer.

Author information

  • 1Center for Radiological Research, Columbia University, New York, NY 10032, USA.

Abstract

Biologically motivated mathematical models are important for understanding the mechanisms of radiation-induced carcinogenesis. Existing models fall into two categories: (1) short-term formalisms, which focus on the processes taking place during and shortly after irradiation (effects of dose, radiation quality, dose rate and fractionation), and (2) long-term formalisms, which track background cancer risks throughout the entire lifetime (effects of age at exposure and time since exposure) but make relatively simplistic assumptions about radiation effects. Grafting long-term mechanisms on to short-term models is badly needed for modelling radiogenic cancer. A combined formalism was developed and applied to cancer risk data in atomic bomb survivors and radiotherapy patients and to background cancer incidence. The data for nine cancer types were described adequately with a set of biologically meaningful parameters for each cancer. These results suggest that the combined short-long-term approach is a potentially promising method for predicting radiogenic cancer risks and interpreting the underlying biological mechanisms.

PMID:
21113062
[PubMed - indexed for MEDLINE]
PMCID:
PMC3108273
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk