Your browser version may not work well with NCBI's Web applications. More information here...
1: Hum Exp Toxicol. 1990 Mar;9(2):105-7.Links

Zolpidem intoxication mimicking narcotic overdose: response to flumazenil.

Lheureux P, Debailleul G, De Witte O, Askenasi R.

Emergency Department and Clinical Toxicology Unit, Erasme University Hospital, Brussels, Belgium.

Zolpidem is a recently introduced sleep-inducer which is thought to act on the central-type benzodiazepine receptors. This observation is the first report of drug poisoning with this compound. The toxic response was characterized by the development of a profound but short-lasting coma, associated with pin-point pupils and respiratory depression, as observed in a narcotic overdose. These clinical signs were not influenced by the administration of naloxone, but responded dramatically to flumazenil. Some analytical data on zolpidem toxicokinetics are presented.

PMID: 2111156 [PubMed - indexed for MEDLINE]

Related Articles

Patient Drug Information
  • Zolpidem (Ambien®, Ambien CR®) Zolpidem is used to treat insomnia (difficulty falling asleep or staying asleep). Zolpidem belongs to a class of medications called sedative-hypnotics. It works by slowing activity in the brain to allow sleep.
    » read more ...